General Information

  • ID:  hor006028
  • Uniprot ID:  Q04618
  • Protein name:  NPP 2
  • Gene name:  pomcb
  • Organism:  Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
  • Family:  POMC family
  • Source:  animal
  • Expression:  Expressed only in sexually active fish.|Pituitary and hypothalamus of adult diploid animals.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Oncorhynchus (genus), Salmoninae (subfamily), Salmonidae (family), Salmoniformes (order), Protacanthopterygii , Euteleosteomorpha (cohort), Clupeocephala , Osteoglossocephalai , Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QCWDSSHCKDLPSEDKILECIHLFRSGLQDESPEPRSAAQQSTEESLSLGILLAALTSGERALDADPEPHSD
  • Length:  72
  • Propeptide:  MFGTFLQNQSVRLNMVCAPWLLAVVVVCVCNPGVEGQCWDSSHCKDLPSEDKILECIHLFRSGLQDESPEPRSAAQQSTEESLSLGILLAALTSGERALDADPEPHSDKRHSYSMEHFRWGKPIGHKRRPIKVYASSLEGGDSSEGTFPLQARRQLSSWEDEMVGALGNQGAKAQTKVVPRTLTVTGLQDKKDGSYRMGHFRWGSPTAIKRYGGFMKPYTQQSHKPLITLLKHVTLKNEQ
  • Signal peptide:  MFGTFLQNQSVRLNMVCAPWLLAVVVVCVCNPGVEG
  • Modification:  T1 Pyrrolidone carboxylic acid
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  [Corticotropin]: Stimulates the adrenal glands to release cortisol.; Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.; Beta-endorphin: Endogenous orexigenic opiate.; [Met-enkephalin]: Endogenous opiate.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q04618-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006028_AF2.pdbhor006028_ESM.pdb

Physical Information

Mass: 912920 Formula: C333H526N94O120S3
Absent amino acids: MNVY Common amino acids: SL
pI: 4.09 Basic residues: 8
Polar residues: 19 Hydrophobic residues: 21
Hydrophobicity: -62.64 Boman Index: -16327
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 78.75
Instability Index: 9152.78 Extinction Coefficient cystines: 5625
Absorbance 280nm: 79.23

Literature

  • PubMed ID:  1448114
  • Title:  One of the two trout proopiomelanocortin messenger RNAs potentially encodes new peptides.